Alfonso Cuarón is back with what appears to be another award-worthy film…

After debuting some of the first footage from his new film, the 51-year-old Mexican filmmaker has released the first trailer for the sci-fi drama Gravity, which stars Sandra Bullock and George Clooney.

The trailer not only that features a breathtaking view of outer space, it shows a nerve-racking experience undergone by Bullock, whose character Dr. Ryan Stone gets into a panic during her first shuttle mission.

The video follows Stone doing a leisure spacewalk in the company of a veteran astronaut when flying debris suddenly hits their craft. “I can’t breathe! What do I do?” Stone says. Completely lost in outer space, she later desperately says, “Anybody, please call me.”

The space-set film centers on Stone, a brilliant medical engineer who is on her first shuttle mission. Accompanied by astronaut Matt Kowalsky, the seemingly routine spacewalk turns into a disaster as their shuttle is destroyed, leaving Stone and Kowalsky completely alone. The deafening silence tells them they’ve lost any link to Earth and any chance for rescue.

The sci-fi film marks the return of Cuarón, who has not helmed a pic since 2006’s Oscar-nominated Children of Men. Taking triple duty in the project, the Mexican filmmaker directs, pens the script with his son Jonas, and co-produces alongside Harry Potter producer David Heyman.

Gravity is set to hit theaters in the U.S. on October 4.