Sandra Bullock hurtles through space in the official trailer for Alfonso Cuarón’s sci-fi thriller Gravity…

The  gripping, anxiety-inducing new clip for the 51-year-old Mexican director’s latest film centers on Bullock’s character, medical engineer Dr. Ryan Stone as she takes part in her first Space Shuttle mission accompanied by veteran astronaut Matt Kowalsky (George Clooney), who is commanding his final expedition.

During a spacewalk, debris from a satellite crashes into the space shuttle Explorer, leaving it mostly destroyed, and stranding them in space with limited air. Without means of communication with Earth, they must cooperate to survive.

Gravity wowed audiences at the Venice Film Festival and Telluride Film Festival. It next hits the Toronto Film Fest before arriving in theaters on October 4.